SCHEMBL8911602

SCHEMBL8911602

COC(=O)CN(C(C)NC(=O)OC(C)(C)C)C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 17/20 0.56
CACNA1F O60840 3/20 0.50
CACNA1D Q01668 3/20 0.50
CACNA1S Q13698 3/20 0.50
CACNA1C Q13936 3/20 0.50
PPARA Q07869 2/20 0.43
PPARG P37231 1/20 0.42
CTSS P25774 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8911598 0.83 TACR1 (0.54) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9391316 0.83 TACR1 (0.67) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910676 0.83 TACR1 (0.65) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911761 0.83 TACR1 (0.67) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8826853 0.83 TACR1 (0.65) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827269 0.82 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827265 0.82 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8458769 0.81 TACR1 (0.64) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8936824 0.81 TACR1 (0.64) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911382 0.81 TACR1 (0.60) TACR1CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5629347-A TACHYKININ ANTAGONIST USED IN TREATMENT OF INFLAMMATION, MIGRAINE, POSTHERPETIC NEURALGIA MERCK SHARP & DOHME LTD. (GB) 1997-05-13 US disclosed
EP-0593557-B1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME (GB) 1996-01-31 EP disclosed
EP-0522808-A2 Aromatic compounds, pharmaceutical compositions containing them and their use in therapy MERCK SHARP & DOHME LTD. (GB) 1993-01-13 EP disclosed