SCHEMBL8912564

SCHEMBL8912564

Cc1cc(C)cc(COCC(NC(=O)OC(C)(C)C)C(c2ccccc2)c2ccccc2)c1

nearest known ligand 0.77

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 16/20 0.77
CACNA1F O60840 2/20 0.63
CACNA1D Q01668 2/20 0.63
CACNA1S Q13698 2/20 0.63
CACNA1C Q13936 2/20 0.63
PPARA Q07869 2/20 0.51
PPARG P37231 1/20 0.49
CTSS P25774 1/20 0.48
KLK5 Q9Y337 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8923781 0.87 TACR1 (1.00) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8879231 0.86 TACR1 (0.60) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8826853 0.86 TACR1 (0.65) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910676 0.86 TACR1 (0.65) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911221 0.83 TACR1 (0.78) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911284 0.81 TACR1 (0.54) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9279559 0.81 ATM (0.58) TACR1PPARAPPARGCTSSKLK5
SCHEMBL9279564 0.81 ATM (0.58) TACR1PPARAPPARGCTSSKLK5
SCHEMBL8911840 0.81 TACR1 (0.61) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910724 0.79 TACR1 (0.83) TACR1CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5629347-A TACHYKININ ANTAGONIST USED IN TREATMENT OF INFLAMMATION, MIGRAINE, POSTHERPETIC NEURALGIA MERCK SHARP & DOHME LTD. (GB) 1997-05-13 US disclosed
EP-0593557-B1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME (GB) 1996-01-31 EP disclosed
EP-0522808-A2 Aromatic compounds, pharmaceutical compositions containing them and their use in therapy MERCK SHARP & DOHME LTD. (GB) 1993-01-13 EP disclosed