Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 19/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL891747 | 0.89 | MCHR1 (0.52) | MCHR1KCNH2 | |
| SCHEMBL891643 | 0.86 | MCHR1 (0.49) | MCHR1KCNH2 | |
| SCHEMBL891268 | 0.84 | MCHR1 (0.44) | MCHR1 | |
| SCHEMBL891931 | 0.84 | MCHR1 (0.51) | MCHR1KCNH2 | |
| SCHEMBL892090 | 0.84 | MCHR1 (0.49) | MCHR1 | |
| SCHEMBL892144 | 0.82 | MCHR1 (0.54) | MCHR1 | |
| SCHEMBL892358 | 0.81 | MCHR1 (0.51) | MCHR1 | |
| SCHEMBL892149 | 0.81 | MCHR1 (0.51) | MCHR1KCNH2 | |
| SCHEMBL892327 | 0.80 | MCHR1 (0.52) | MCHR1KCNH2 | |
| SCHEMBL891839 | 0.79 | MCHR1 (0.52) | MCHR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083489-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | GLAXOSMITHKLINE LLC | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083489-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | MCHR1, MCHR2, MC1R | MCHR1 1/4885SIGMAR1 73/4885KCNH2 3409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.