Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912358 | 0.87 | PDE3B (0.38) | PDE3BPDE3AMAPTP2RX7PDE4A | |
| SCHEMBL8302588 | 0.84 | PDE3B (0.44) | PDE3BPDE3AMAPTPDE4APDE4B | |
| Bromide SCHEMBL9235635 | 0.83 | PDE3B (0.43) | PDE3BPDE3AMAPTPDE4APDE4B | |
| SCHEMBL8911600 | 0.82 | CA12 (0.52) | PDE3BPDE3AMAPTP2RX7PDE4A | |
| SCHEMBL8296106 | 0.80 | PDE3B (0.43) | PDE3BPDE3AMAPTP2RX7PDE4A | |
| SCHEMBL8912025 | 0.80 | PDE4A (0.40) | PDE3BPDE3AMAPTP2RX7PDE4A | |
| Bromide SCHEMBL8291044 | 0.79 | PDE3B (0.42) | PDE3BPDE3AMAPTP2RX7PDE4A | |
| SCHEMBL8292411 | 0.77 | PDE3B (0.42) | PDE3BPDE3AMAPTP2RX7PDE4A | |
| SCHEMBL8307491 | 0.77 | GRIA2 (0.45) | PDE3BPDE3AMAPTPDE4APDE4B | |
| SCHEMBL8302569 | 0.76 | MAPT (0.42) | PDE3BPDE3AMAPTPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605901-A | THERAPY FOR GRAM-NEGATIVE BACTERIA, NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5543409-A | Indane derivatives for treating endotoxin shock and/or nephritis | TANABE SEIYAKU CO., LTD. (JP) | 1996-08-06 | — | — | US | disclosed |
| EP-0661274-A1 | Indane derivatives, processes for preparing the same and synthetic intermediate of the same | TANABE SEIYAKU CO., LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |