Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 7/20 | 0.66 |
| ▸ | HTR1D | P28221 | 5/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | HTR6 | P50406 | 9/20 | 0.57 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913542 | 1.00 | HTR1B (0.66) | HTR1BHTR1DHTR1AHTR6NOS3 | |
| SCHEMBL8913545 | 1.00 | HTR1B (0.66) | HTR1BHTR1DHTR1AHTR6NOS3 | |
| SCHEMBL8915034 | 0.88 | HTR1B (0.63) | HTR1BHTR1DHTR1AHTR6NOS3 | |
| SCHEMBL8915028 | 0.88 | HTR1B (0.63) | HTR1BHTR1DHTR1AHTR6NOS3 | |
| SCHEMBL27316936 | 0.87 | HTR1B (0.62) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL14593919 | 0.86 | HTR1B (0.69) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8479254 | 0.85 | HTR1B (0.71) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8479248 | 0.85 | HTR1B (0.71) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8913670 | 0.84 | HTR1B (0.63) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8914084 | 0.84 | HTR1B (0.66) | HTR1BHTR1DHTR1AHTR6NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |