Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 10/20 | 0.32 |
| ▸ | MMP3 | P08254 | 9/20 | 0.32 |
| ▸ | STAT6 | P42226 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 3/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14568138 | 1.00 | TUBB1 (0.53) | TUBB1MMP2MMP3STAT6POLB | |
| SCHEMBL58323 | 1.00 | TUBB1 (0.53) | TUBB1MMP2MMP3STAT6POLB | |
| SCHEMBL6671759 | 0.93 | TUBB1 (0.51) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL6671761 | 0.93 | TUBB1 (0.51) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL6671755 | 0.93 | TUBB1 (0.51) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL58218 | 0.93 | TUBB1 (0.51) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL13682030 | 0.90 | TUBB1 (0.56) | TUBB1MMP2MMP3STAT6POLB | |
| SCHEMBL58781 | 0.90 | TUBB1 (0.56) | TUBB1MMP2MMP3STAT6POLB | |
| SCHEMBL13848318 | 0.90 | TUBB1 (0.61) | TUBB1MMP2MMP3STAT6MMP1 | |
| SCHEMBL58029 | 0.90 | TUBB1 (0.61) | TUBB1MMP2MMP3STAT6MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |