Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504470 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504382 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504203 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504883 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504069 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504425 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504426 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504383 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504070 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 | |
| SCHEMBL504882 | 0.99 | HRH4 (0.42) | HRH4ADRB2ADRB1ADRB3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |
| US-5563160-A | NERVOUS SYSTEM DISORDERS, ANTIHISTAMINE, ANTIALLERGENS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1996-10-08 | — | — | US | disclosed |
| EP-0660823-B1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1996-08-14 | — | — | EP | disclosed |