Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.37 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10649424 | 0.90 | NOTUM (0.57) | NOTUMHSP90AA1KCNQ2GRM5PRMT5 | |
| SCHEMBL1425282 | 0.81 | PRMT5 (0.47) | KCNQ2PRMT5WDR77 | |
| SCHEMBL23018016 | 0.80 | HSP90AA1 (0.42) | HSP90AA1KCNQ2RIPK1PRMT5WDR77 | |
| SCHEMBL8680487 | 0.80 | NOTUM (0.57) | NOTUMHSP90AA1KCNQ2PRMT5WDR77 | |
| SCHEMBL7795095 | 0.80 | ESR2 (0.49) | HSP90AA1KCNQ2RIPK1PRMT5WDR77 | |
| SCHEMBL21899394 | 0.75 | HSP90AA1 (0.55) | NOTUMHSP90AA1KCNQ2GRM5PRMT5 | |
| SCHEMBL7227468 | 0.75 | NOTUM (0.80) | NOTUMRIPK1PRMT5WDR77 | |
| SCHEMBL7880301 | 0.73 | HSP90AA1 (0.47) | NOTUMHSP90AA1KCNQ2GRM5PRMT5 | |
| SCHEMBL15492426 | 0.73 | HSP90AA1 (0.50) | HSP90AA1KCNQ2GRM5PRMT5WDR77 | |
| SCHEMBL12810928 | 0.72 | AKR1C3 (0.45) | HSP90AA1KCNQ2RIPK1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691330-A | ANTIPSYCHOTIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5532240-A | ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0596125-A1 | CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |