Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 19/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917898 | 1.00 | TACR1 (0.79) | TACR1CYP2D6KCNH2 | |
| SCHEMBL9295254 | 1.00 | TACR1 (0.79) | TACR1CYP2D6KCNH2 | |
| Cp-99994 SCHEMBL29375350 | 0.88 | TACR1 (1.00) | TACR1CYP2D6KCNH2 | |
| Cp-99994 SCHEMBL1282327 | 0.88 | TACR1 (1.00) | TACR1CYP2D6KCNH2 | |
| Cp-99994 SCHEMBL3951618 | 0.88 | TACR1 (1.00) | TACR1CYP2D6KCNH2 | |
| Cp-99994 SCHEMBL14513344 | 0.88 | TACR1 (1.00) | TACR1CYP2D6KCNH2 | |
| Cp-99994 SCHEMBL3951615 | 0.88 | TACR1 (1.00) | TACR1CYP2D6KCNH2 | |
| Cp-99994 SCHEMBL6827944 | 0.88 | TACR1 (1.00) | TACR1CYP2D6KCNH2 | |
| Cp-99994 SCHEMBL9295413 | 0.88 | TACR1 (1.00) | TACR1CYP2D6KCNH2 | |
| SCHEMBL22272192 | 0.87 | TACR1 (0.72) | TACR1CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686615-A | HYDROGENATION OF A PYRIDINE COMPOUND IN THE PRESENCE OF A METAL CATALYST | PFIZER INC (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0436334-B1 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5332817-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1994-07-26 | — | — | US | disclosed |
| EP-0581777-A1 | STEREOSELECTIVE PREPARATION OF SUBSTITUTED PIPERIDINES | PFIZER INC. (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5232929-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1992017449-A1 | STEREOSELECTIVE PREPARATION OF SUBSTITUTED PIPERIDINES | PFIZER INC. (US) | 1992-10-15 | — | — | WO | disclosed |
| EP-0436334-A2 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |