SCHEMBL8918239

SCHEMBL8918239

Cn1nc(C(N)=O)c(Cl)c1OC(F)F

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.31
KDM4E B2RXH2 1/20 0.30
CCNA2 P20248 1/20 0.30
CDK2 P24941 1/20 0.30
CCNA1 P78396 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8434714 0.83 NPSR1 (0.36) POLBKDM4E
SCHEMBL8643828 0.83 CCNA2 (0.33) KDM4ECCNA2CDK2CCNA1
SCHEMBL8921518 0.75 SCN9A (0.34)
SCHEMBL8623813 0.73 GRM5 (0.31)
SCHEMBL13693059 0.73 KDM4E (0.35) KDM4E
SCHEMBL22488066 0.71
SCHEMBL8921488 0.71
SCHEMBL8652790 0.71 KDM4E (0.33) KDM4E
SCHEMBL18241102 0.71 PTGER4 (0.31) KDM4E
SCHEMBL8409622 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5668278-A HERBICIDES AND CHEMICAL INTERMEDIATES HOESCHST SCHERING AGREVO GMBH (DE) 1997-09-16 US disclosed
CN-1033805-C Substituted pyrazolyl pyrazole, its preparation process and intermediate, and application as herbicide SCHERING AG (DE) 1997-01-15 CN disclosed
US-5556986-A CHEMICAL INTERMEDIATES FOR PYRAZOLYLPYRAZOLES AS HERBICIDES HOECHST SCHERING AGREVO GMBH (DE) 1996-09-17 US disclosed
EP-0643700-B1 NEW SUBSTITUTED PYRAZOLYLPYRAZOLES, PROCESSES FOR THEIR PREPARATION, AS WELL AS INTERMEDIATES, AND THEIR USE AS HERBICIDES HOECHST SCHERING AGREVO GMBH (DE) 1996-09-11 EP disclosed
US-5405829-A Substituted pyrazolypyrazoles and their use as herbicides SCHERING AKTIENGESELLSCHAFT (DE) 1995-04-11 US disclosed
EP-0643700-A1 NEW SUBSTITUTED PYRAZOLYLPYRAZOLES, PROCESSES FOR THEIR PREPARATION, AS WELL AS INTERMEDIATES, AND THEIR USE AS HERBICIDES. SCHERING AG (DE) 1995-03-22 EP disclosed
CN-1073440-A The pyrazolyl-pyrazole of new replacement, its preparation method, and their intermediate and they are as the purposes of weedicide SCHERING AG (DE) 1993-06-23 CN disclosed
WO-1993010100-A1 NEW SUBSTITUTED PYRAZOLYLPYRAZOLES, PROCESSES FOR THEIR PREPARATION, AS WELL AS INTERMEDIATES, AND THEIR USE AS HERBICIDES SCHERING AKTIENGESELLSCHAFT (DE) 1993-05-27 WO disclosed
EP-0542388-A1 New substituted pyrazolylpyrazoles, processes for their preparation, as well as intermediates, and their use as herbicides SCHERING AKTIENGESELLSCHAFT (DE) 1993-05-19 EP disclosed