SCHEMBL8919399

SCHEMBL8919399

CC1CCCCN1c1c(-c2ccc(F)c(F)c2)c(Cl)nc2ncnn12

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
EGLN2 Q96KS0 1/20 0.43
PDE2A O00408 18/20 0.40
GLA P06280 1/20 0.36
TSHR P16473 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7491339 0.88 EGLN2 (0.41) EGLN2PDE2AGLATSHRNPSR1
SCHEMBL7821904 0.85 PDE2A (0.39) EGLN2PDE2AGLATSHRNPSR1
SCHEMBL7493479 0.85 EGLN2 (0.43) EGLN2PDE2AGLATSHRNPSR1
SCHEMBL4821125 0.84 TP53 (0.45) EGLN2PDE2ATSHR
SCHEMBL4819382 0.84 PDE2A (0.43) EGLN2PDE2ATSHRNPSR1
SCHEMBL4820964 0.84 PDE2A (0.42) EGLN2PDE2AGLATSHRNPSR1
SCHEMBL8913698 0.83 KDM4E (0.40) EGLN2PDE2ATSHR
SCHEMBL8915863 0.83 TSHR (0.42) EGLN2PDE2AGLATSHRNPSR1
SCHEMBL4820351 0.83 TSHR (0.45) EGLN2PDE2ATSHRNPSR1
SCHEMBL4819706 0.82 PDE2A (0.40) EGLN2PDE2AGLATSHRNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5593996-A FUNGICIDES AMERICAN CYANAMID COMPANY (US) 1997-01-14 US disclosed