Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.53 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.53 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | QPCT | Q16769 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920957 | 0.94 | NAMPT (0.57) | NAMPTP2RX7CYP3A4CYP2D6MEN1 | |
| SCHEMBL8916138 | 0.93 | NAMPT (0.61) | NAMPTP2RX7CYP3A4CYP2D6MEN1 | |
| SCHEMBL810245 | 0.92 | NAMPT (0.63) | NAMPTP2RX7CYP3A4CYP2D6MEN1 | |
| SCHEMBL810429 | 0.92 | NAMPT (0.63) | NAMPTP2RX7CYP3A4CYP2D6MEN1 | |
| SCHEMBL810488 | 0.92 | NAMPT (0.63) | NAMPTP2RX7CYP3A4CYP2D6MEN1 | |
| SCHEMBL810735 | 0.92 | NAMPT (0.63) | NAMPTP2RX7CYP3A4CYP2D6MEN1 | |
| SCHEMBL810197 | 0.92 | NAMPT (0.63) | NAMPTP2RX7CYP3A4CYP2D6MEN1 | |
| SCHEMBL810168 | 0.92 | NAMPT (0.63) | NAMPTP2RX7CYP3A4CYP2D6MEN1 | |
| SCHEMBL8919397 | 0.87 | NAMPT (0.67) | NAMPTP2RX7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL809999 | 0.83 | NAMPT (0.78) | NAMPTP2RX7CYP3A4CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |
| US-5563160-A | NERVOUS SYSTEM DISORDERS, ANTIHISTAMINE, ANTIALLERGENS | Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1996-10-08 | — | — | US | disclosed |
| EP-0660823-B1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | LEO PHARM PROD LTD (DK) | 1996-08-14 | — | — | EP | disclosed |
| EP-0660823-A1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS. | LEO PHARM PROD LTD (DK) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006770-A1 | N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1994-03-31 | — | — | WO | disclosed |