Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SREBF2 | Q12772 | 4/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | DCK | P27707 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923733 | 0.91 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7494039 | 0.85 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8922821 | 0.85 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL3589668 | 0.85 | KDM4E (0.58) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8925973 | 0.84 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8925953 | 0.83 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DMAPT | |
| Tetomilast SCHEMBL29369138 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMAPT | |
| Tetomilast SCHEMBL436663 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMAPT | |
| Methylene Chloride SCHEMBL28013639 | 0.82 | KDM4E (0.60) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL852122 | 0.82 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |