Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.45 |
| ▸ | ECE1 | P42892 | 5/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923159 | 1.00 | MME (0.45) | MMEECE1AGTR2HCAR2IDH1 | |
| SCHEMBL8921967 | 0.96 | MME (0.46) | MMEECE1AGTR2HCAR2POLB | |
| SCHEMBL8921961 | 0.96 | MME (0.46) | MMEECE1AGTR2HCAR2POLB | |
| SCHEMBL8920944 | 0.92 | ECE1 (0.52) | MMEECE1AGTR2 | |
| SCHEMBL8920954 | 0.92 | ECE1 (0.52) | MMEECE1AGTR2 | |
| SCHEMBL8922375 | 0.91 | MME (0.42) | MMEECE1AGTR2HCAR2POLB | |
| SCHEMBL8922366 | 0.91 | MME (0.42) | MMEECE1AGTR2HCAR2POLB | |
| SCHEMBL8922277 | 0.90 | MME (0.51) | MMEECE1AGTR2IDH1XDH | |
| SCHEMBL8922235 | 0.90 | MME (0.51) | MMEECE1AGTR2IDH1XDH | |
| SCHEMBL8923075 | 0.89 | ECE1 (0.46) | MMEECE1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660840-B1 | PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5550119-A | ENDOTHELIN-CONVERTING ENZYM INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1996-08-27 | — | — | US | disclosed |
| US-5273990-A | 5-Phosphonomethyleneamino aryl-substitued alkylene-1H-tetazoles | CIBA-GEIGY CORPORATION (US) | 1993-12-28 | — | — | US | disclosed |