Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 20/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6653500 | 0.88 | TYMS (1.00) | TYMS | |
| SCHEMBL6653412 | 0.87 | TYMS (1.00) | TYMS | |
| SCHEMBL6649299 | 0.79 | TYMS (1.00) | TYMS | |
| SCHEMBL6651319 | 0.77 | TYMS (1.00) | TYMS | |
| SCHEMBL6650266 | 0.77 | TYMS (1.00) | TYMS | |
| SCHEMBL30589037 | 0.77 | TYMS (1.00) | TYMS | |
| SCHEMBL6654365 | 0.77 | TYMS (1.00) | TYMS | |
| SCHEMBL11609746 | 0.76 | TYMS (0.75) | TYMS | |
| SCHEMBL6653029 | 0.75 | TYMS (0.81) | TYMS | |
| SCHEMBL6649167 | 0.75 | TYMS (1.00) | TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661155-A | THYMIDYLATE SYNTHASE INHIBITOR; ADMINISTERING TO THE MAMMAL SUFFERING FROM LEUKEMIA OR TUMOR 2-(5-(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLINE-9-YL) METHYL)AMINO)-1-OXO-2-ISOINDOLINYL)GLUTARIC ACID OR SALTS | GLAXO WELLCOME INC. (US) | 1997-08-26 | — | — | US | disclosed |