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SCHEMBL8924038

SCHEMBL8924038

COC(C(=O)NCCCCCCCCNC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)C(=O)NCCCCN(CCC(C)NC(=O)OC(C)(C)C)Cc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ APP P05067 2/20 0.37
▸ MAPT P10636 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ SIRT2 Q8IXJ6 1/20 0.35
▸ PTPN1 P18031 4/20 0.35
▸ PTPRA P18433 1/20 0.35
▸ PTPN22 Q9Y2R2 1/20 0.35
▸ CTSK P43235 3/20 0.35
▸ CTSS P25774 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8924021 1.00 APP (0.37) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8919864 1.00 APP (0.37) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8919876 1.00 APP (0.37) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8924035 0.93 MAPT (0.38) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8920908 0.93 MAPT (0.38) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8924022 0.93 MAPT (0.38) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8920924 0.93 MAPT (0.38) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8921779 0.92 APP (0.37) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8921767 0.92 APP (0.37) APPMAPTMEN1KMT2ASIRT2
SCHEMBL8923113 0.92 APP (0.37) APPMAPTMEN1KMT2ASIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5637613-A ANTITUMOR AGENT; IMMUNOSUPPRESSANTS FOURNIER INDUSTRIE ET SANTE (FR) 1997-06-10 — — US disclosed