Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.66 |
| ▸ | CA2 | P00918 | 2/20 | 0.66 |
| ▸ | CSF1R | P07333 | 2/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.66 |
| ▸ | FLT3 | P36888 | 1/20 | 0.66 |
| ▸ | FRK | P42685 | 1/20 | 0.66 |
| ▸ | CLK2 | P49760 | 1/20 | 0.66 |
| ▸ | GSK3A | P49840 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.66 |
| ▸ | STK3 | Q13188 | 1/20 | 0.66 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.66 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923677 | 0.86 | CYP1A2 (0.76) | CA1CA2CSF1RROCK2MAP4K4 | |
| SCHEMBL1612505 | 0.82 | KDM4E (0.79) | KDM4ECYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL8924448 | 0.80 | KDM4E (0.59) | CA1CA2KDM4ECYP1A2POLB | |
| SCHEMBL9363357 | 0.79 | CSF1R (1.00) | CA1CA2CSF1RROCK2MAP4K4 | |
| SCHEMBL13408273 | 0.79 | CA1 (0.58) | CA1CA2CSF1RROCK2MAP4K4 | |
| SCHEMBL1054072 | 0.78 | FGFR1 (0.74) | — | |
| SCHEMBL8924998 | 0.78 | MAP2 (0.54) | CA1CA2CSF1RROCK2MAP4K4 | |
| SCHEMBL8543837 | 0.77 | CA1 (0.67) | CA1CA2KDM4ECYP1A2POLB | |
| SCHEMBL9542194 | 0.77 | CYP1A2 (0.62) | KDM4ECYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL4851140 | 0.77 | CSF1R (0.76) | CA1CA2CSF1RROCK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | claimed |
| US-5614532-A | NERVOUS SYSTEM DISORDERS USING N-METHYLASPARTATE ANTAGONIST | MERCK, SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |
| EP-0620812-A1 | QUINOLONE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |