Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | CDC25C | P30307 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8926273 | 0.84 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6199367 | 0.80 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6194685 | 0.80 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7499485 | 0.79 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6202837 | 0.79 | SREBF2 (0.60) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6199824 | 0.79 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7502906 | 0.78 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6197296 | 0.78 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6201319 | 0.78 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Hydrochloric Acid SCHEMBL6199487 | 0.78 | SREBF2 (0.59) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |