Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | EIF4E | P06730 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923878 | 0.89 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8924565 | 0.89 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8925296 | 0.88 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8924710 | 0.88 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8924336 | 0.87 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| Tetomilast SCHEMBL29369138 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| Tetomilast SCHEMBL436663 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6199367 | 0.85 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6199639 | 0.84 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL6197296 | 0.84 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |