SCHEMBL8924869

SCHEMBL8924869

O=C/C=C1/CCCc2ccccc21

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.52
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52
CYP19A1 P11511 6/20 0.51
CYP11B2 P19099 6/20 0.51
CYP11B1 P15538 5/20 0.51
MAPT P10636 3/20 0.51
MIF P14174 2/20 0.51
SMN1; SMN2 Q16637 3/20 0.46
ALDH1A1 P00352 2/20 0.46
NPC1 O15118 1/20 0.46
TP53 P04637 1/20 0.46
NFKB1 P19838 1/20 0.46
RAB9A P51151 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
LMNA P02545 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
HTT P42858 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8919645 1.00 CYP2A6 (0.52) CYP2A6MAOAMAOBCYP19A1CYP11B2
SCHEMBL31660831 0.88 CES1 (0.50) MAOBCYP19A1CYP11B2CYP11B1MAPT
SCHEMBL9421087 0.84 CYP19A1 (0.44) CYP2A6MAOAMAOBCYP19A1CYP11B2
SCHEMBL9421082 0.84 CYP19A1 (0.44) CYP2A6MAOAMAOBCYP19A1CYP11B2
SCHEMBL10533603 0.84 CYP19A1 (0.44) CYP2A6MAOAMAOBCYP19A1CYP11B2
SCHEMBL9421122 0.84 CYP19A1 (0.44) CYP2A6MAOAMAOBCYP19A1CYP11B2
SCHEMBL5921441 0.81 CYP19A1 (0.51) CYP2A6MAOAMAOBCYP19A1CYP11B2
SCHEMBL17680269 0.78 CYP19A1 (0.56) CYP2A6MAOAMAOBCYP19A1CYP11B2
SCHEMBL30436320 0.76 CYP2A6 (0.65) CYP2A6MAOAMAOBCYP19A1CYP11B2
SCHEMBL9652088 0.76 CYP2A6 (0.65) CYP2A6MAOAMAOBCYP19A1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0802897-A1 NOVEL COMPOUNDS Smithkline Beecham S.p.A. (IT) 1997-10-29 EP disclosed
WO-1996021638-A1 NOVEL COMPOUNDS SMITHKLINE BEECHAM S.P.A. (IT) 1996-07-18 WO disclosed