Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | EIF4E | P06730 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.42 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | CDC25C | P30307 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653565 | 0.90 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DEIF4E | |
| SCHEMBL8922392 | 0.87 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8926285 | 0.86 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8925279 | 0.82 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6202491 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DEIF4E | |
| SCHEMBL8923439 | 0.81 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6201287 | 0.80 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DEIF4E | |
| SCHEMBL8923947 | 0.80 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6199321 | 0.80 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6197559 | 0.79 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DEIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |