Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.81 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.81 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1545319 | 0.90 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DMAPT | |
| Tetomilast SCHEMBL29369138 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMAPT | |
| Tetomilast SCHEMBL436663 | 0.89 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL21653506 | 0.88 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7499977 | 0.88 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6197199 | 0.87 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL9412984 | 0.84 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8925279 | 0.83 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8922503 | 0.82 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8922514 | 0.82 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |