Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 19/20 | 0.71 |
| ▸ | TACR3 | P29371 | 2/20 | 0.61 |
| ▸ | RHOC | P08134 | 1/20 | 0.50 |
| ▸ | RHOA | P61586 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8821427 | 1.00 | TACR1 (0.71) | TACR1TACR3RHOCRHOA | |
| SCHEMBL8821525 | 0.95 | TACR1 (0.69) | TACR1TACR3 | |
| SCHEMBL8821711 | 0.95 | TACR1 (0.69) | TACR1TACR3 | |
| SCHEMBL8821324 | 0.95 | TACR1 (0.78) | TACR1TACR3 | |
| SCHEMBL8821328 | 0.95 | TACR1 (0.78) | TACR1TACR3 | |
| SCHEMBL8821540 | 0.92 | TACR1 (0.70) | TACR1TACR3 | |
| SCHEMBL8924197 | 0.92 | TACR1 (0.70) | TACR1TACR3 | |
| SCHEMBL8924388 | 0.91 | TACR1 (0.73) | TACR1TACR3 | |
| SCHEMBL8821562 | 0.91 | TACR1 (0.73) | TACR1TACR3 | |
| SCHEMBL8821641 | 0.89 | TACR1 (0.74) | TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646144-A | FOR TREATING DISORDERS IN WHICH SUBSTANCE P PLAYS A PART IN DEVELOPMENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | claimed |
| EP-0532456-B1 | 1-Acylpiperidine derivatives and their use as substance P antagonists | CIBA GEIGY AG (CH) | 1995-03-29 | — | — | EP | claimed |
| EP-0532456-A1 | 1-Acylpiperidine derivatives and their use as substance P antagonists | CIBA-GEIGY AG (CH) | 1993-03-17 | — | — | EP | claimed |
| US-5646144-A | FOR TREATING DISORDERS IN WHICH SUBSTANCE P PLAYS A PART IN DEVELOPMENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5541195-A | SUBSTANCE P ANTAGONISTS | CIBA-GEIGY CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0532456-B1 | 1-Acylpiperidine derivatives and their use as substance P antagonists | CIBA GEIGY AG (CH) | 1995-03-29 | — | — | EP | disclosed |
| US-5310743-A | Substance P antagonist | CIBA-GEIGY CORP. (US) | 1994-05-10 | — | — | US | disclosed |
| EP-0532456-A1 | 1-Acylpiperidine derivatives and their use as substance P antagonists | CIBA-GEIGY AG (CH) | 1993-03-17 | — | — | EP | disclosed |