Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.49 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8925279 | 0.88 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8924567 | 0.87 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DMAPT | |
| Hydrochloric Acid SCHEMBL8924752 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL8923403 | 0.83 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6194685 | 0.80 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6200825 | 0.79 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6199824 | 0.79 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6197559 | 0.78 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6201957 | 0.78 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DMAPT | |
| Hydrochloric Acid SCHEMBL6196997 | 0.78 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |