SCHEMBL8927119

SCHEMBL8927119

Nc1nc(=O)n(C(=O)C(F)(F)[C@H](F)[C@H](O)CO)cc1Cl

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TET2 Q6N021 1/20 0.30
TET1 Q8NFU7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8743135 0.89 TET2 (0.30) TET2TET1
SCHEMBL8742889 0.89 TET2 (0.30) TET2TET1
SCHEMBL8743124 0.89 TET2 (0.30) TET2TET1
SCHEMBL8742913 0.76 ALB (0.35)
SCHEMBL8743028 0.76 ALB (0.35)
SCHEMBL8743024 0.76 ALB (0.35)
SCHEMBL9139334 0.75
SCHEMBL8743038 0.75
SCHEMBL8743076 0.75 EP300 (0.31)
SCHEMBL8743034 0.75 EP300 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5644043-A ANTITUMOR, ANTICANCER, TREATMENT OF HERPES ELI LILLY AND COMPANY (US) 1997-07-01 US disclosed
US-5574021-A LEUKEMIA ELI LILLY AND COMPANY (US) 1996-11-12 US disclosed
EP-0329348-B1 2',3'-Dideoxy-2',2'-difluoronucleosides LILLY CO ELI (US) 1995-07-12 EP disclosed
EP-0329348-A2 2',3'-Dideoxy-2',2'-difluoronucleosides ELI LILLY AND COMPANY (US) 1989-08-23 EP disclosed