SCHEMBL8927176

SCHEMBL8927176

c1ccc2c(c1)OCC(C1CCCCC1)O2

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 2/20 0.55
CHRNA3 P32297 2/20 0.55
CHRNB2 P17787 1/20 0.55
CHRNA4 P43681 1/20 0.55
LTA4H P09960 1/20 0.46
ADRA2A P08913 1/20 0.45
ADRA2B P18089 1/20 0.45
ADRA2C P18825 1/20 0.45
ADRA1D P25100 1/20 0.45
ADRA1A P35348 1/20 0.45
ADRA1B P35368 1/20 0.45
SCN1A P35498 1/20 0.45
SCN2A Q99250 1/20 0.45
SCN3A Q9NY46 1/20 0.45
TSHR P16473 1/20 0.44
NISCH Q9Y2I1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18374091 0.90 CHRNB4 (0.56) CHRNB4CHRNA3CHRNB2CHRNA4NISCH
SCHEMBL16731499 0.80 CHRNB4 (0.61) CHRNB4CHRNA3CHRNB2CHRNA4LTA4H
SCHEMBL10025601 0.76 STS (0.34) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL10025602 0.76 STS (0.34) CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL11305709 0.76 CHRNB4 (0.53) CHRNB4CHRNA3CHRNB2CHRNA4NISCH
SCHEMBL7441397 0.76 CHRNB4 (0.53) CHRNB4CHRNA3CHRNB2CHRNA4NISCH
SCHEMBL11305978 0.76 CHRNB4 (0.53) CHRNB4CHRNA3CHRNB2CHRNA4NISCH
SCHEMBL11046521 0.76 CHRNB4 (0.53) CHRNB4CHRNA3CHRNB2CHRNA4NISCH
SCHEMBL9774593 0.76 CHRNB4 (0.53) CHRNB4CHRNA3CHRNB2CHRNA4NISCH
SCHEMBL11291799 0.76 CHRNB4 (0.53) CHRNB4CHRNA3CHRNB2CHRNA4NISCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5658941-A PSYCHOLOGICAL DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 1997-08-19 US disclosed
US-5496847-A ANXIOLYTIC AND ANTIDEPRESSANT BRISTOL-MYERS SQUIBB CO. (US) 1996-03-05 US disclosed
US-5391570-A Anxiolytic agents; antidepressants BRISTOL-MYERS SQUIBB (US) 1995-02-21 US disclosed