Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.62 |
| ▸ | TTBK1 | Q5TCY1 | 10/20 | 0.57 |
| ▸ | TTBK2 | Q6IQ55 | 10/20 | 0.57 |
| ▸ | AKT1 | P31749 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787013 | 0.97 | EGFR (0.59) | EGFRTTBK1TTBK2AKT1AURKA | |
| Hydrochloric Acid SCHEMBL8929628 | 0.96 | EGFR (0.58) | EGFRTTBK1TTBK2AKT1AURKA | |
| SCHEMBL8929866 | 0.79 | EGFR (0.51) | EGFRTTBK1TTBK2AKT1AURKA | |
| Hydrochloric Acid SCHEMBL8929855 | 0.78 | EGFR (0.50) | EGFRTTBK1TTBK2AKT1AURKA | |
| SCHEMBL27460612 | 0.75 | TTBK1 (0.69) | EGFRTTBK1TTBK2AKT1AURKA | |
| SCHEMBL1095145 | 0.72 | EGFR (0.57) | EGFR | |
| SCHEMBL8976249 | 0.72 | EGFR (0.65) | EGFRMKNK1 | |
| SCHEMBL27930913 | 0.72 | TTBK1 (0.64) | EGFRTTBK1TTBK2AKT1AURKA | |
| SCHEMBL12101466 | 0.72 | MEN1 (0.56) | EGFR | |
| SCHEMBL8929392 | 0.72 | EGFR (0.58) | EGFRTTBK1TTBK2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | claimed |
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | disclosed |