Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.69 |
| ▸ | EGFR | P00533 | 5/20 | 0.66 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.64 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.59 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL958582 | 0.88 | EGFR (0.69) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL6283205 | 0.85 | EGFR (0.70) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL6811506 | 0.84 | EGFR (0.69) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL1557011 | 0.84 | FFAR1 (0.71) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL4152328 | 0.83 | EGFR (0.72) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL27517502 | 0.83 | EGFR (0.68) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL19753722 | 0.83 | EGFR (0.64) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL2013554 | 0.83 | PARP10 (0.71) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL23782481 | 0.82 | EGFR (0.67) | PARP10EGFRNR4A1NR4A2NR4A3 | |
| SCHEMBL119689 | 0.82 | PARP10 (1.00) | PARP10NR4A1NR4A2NR4A3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997028161-A1 | NOVEL PYRROLO[2,3-D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 1997-08-07 | — | — | WO | disclosed |