Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930534 | 1.00 | HRH4 (0.58) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL8930476 | 0.86 | HRH4 (0.67) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL8930480 | 0.86 | HRH4 (0.67) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL9078990 | 0.86 | HRH4 (0.67) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL9079680 | 0.80 | HRH4 (0.71) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL8930489 | 0.80 | HRH4 (0.71) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL9081964 | 0.80 | HRH4 (0.71) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL8930496 | 0.80 | HRH4 (0.71) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL3836813 | 0.75 | HRH4 (0.74) | HRH4KDM4ELMNADRD2HRH2 | |
| SCHEMBL8204367 | 0.75 | DRD1 (0.55) | HRH4KDM4ELMNADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996018621-A1 | ALKYL-SUBSTITUTED COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (US) | 1996-06-20 | — | — | WO | claimed |
| US-5602121-A | ANTISCHIZOPHRENIA AGENTS | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1997-02-11 | — | — | US | disclosed |
| WO-1996018621-A1 | ALKYL-SUBSTITUTED COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (US) | 1996-06-20 | — | — | WO | disclosed |