Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 19/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893383 | 1.00 | CYP3A4 (0.55) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| Hydrochloric Acid SCHEMBL31236647 | 0.99 | CYP3A4 (0.55) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| Hydrochloric Acid SCHEMBL7389969 | 0.99 | CYP3A4 (0.55) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| SCHEMBL7196078 | 0.98 | CYP3A4 (0.54) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| SCHEMBL7181197 | 0.98 | CYP3A4 (0.54) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| SCHEMBL893460 | 0.90 | CYP3A4 (0.62) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| SCHEMBL2954848 | 0.90 | CYP3A4 (0.62) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| SCHEMBL16281945 | 0.89 | CYP3A4 (0.59) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| SCHEMBL4956629 | 0.88 | CYP3A4 (0.61) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 | |
| SCHEMBL4961170 | 0.88 | CYP3A4 (0.61) | CYP3A4MEN1SLC22A2SLC22A1ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112500367-A | Refining method of ritonavir intermediate | 盐城迪赛诺制药有限公司 | 2021-03-16 | — | — | CN | claimed |
| EP-0997459-B1 | Intermediates for preparing retroviral protease inhibiting compounds | ABBOTT LAB (US) | 2008-11-26 | — | — | EP | claimed |
| US-6667404-B2 | Carbamylation of 1-amino group of 1,4-amino-3-hydroxybutane derivative with an organocarbonate containing thiazolyl, oxazolyl, isoxazolyl or isothiazolyl substituent | ABBOTT LABORATORIES | 2003-12-23 | — | — | US | claimed |
| EP-1302468-A1 | Processes and intermediates for manufacturing retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 2003-04-16 | — | — | EP | claimed |
| EP-0830353-B1 | PROCESS FOR THE PREPARATION OF AN HIV PROTEASE INHIBITING COMPOUND | ABBOTT LAB (US) | 2002-04-24 | — | — | EP | claimed |
| EP-1090914-A2 | Processes and intermediates for manufacturing retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | claimed |
| US-6150530-A | AMIDATION OF AMINE WITH ACID | ABBOTT LABORATORIES (US) | 2000-11-21 | — | — | US | claimed |
| EP-0830353-A1 | PROCESS FOR THE PREPARATION OF AN HIV PROTEASE INHIBITING COMPOUND | Abbott Laboratories (US) | 1998-03-25 | — | — | EP | claimed |
| US-5659045-A | AIDS THERAPY | ABBOTT LABORATORIES (US) | 1997-08-19 | — | — | US | claimed |
| WO-1996039398-A1 | PROCESS FOR THE PREPARATION OF AN HIV PROTEASE INHIBITING COMPOUND | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | claimed |
| US-5567823-A | Process for the preparation of an HIV protease inhibiting compound | ABBOTT LABORATORIES (US) | 1996-10-22 | — | — | US | claimed |
| US-5565418-A | PREPARING CARBAMATE INTERMEDIATES BY REACTING SUBSTITUTED HYDROXYDIAMINE COMPOUND WITH ONE AMINE PROTECTED WITH ACTIVATED ACYLATING AGENT, DEPROTECTING | ABBOTT LABORATORIES (US) | 1996-10-15 | — | — | US | claimed |
| EP-0727419-A2 | Retroviral protease inhibiting compounds | Abbott Laboratories (US) | 1996-08-21 | — | — | EP | claimed |
| US-5541334-A | TREATING HIV | ABBOTT LABORATORIES (US) | 1996-07-30 | — | — | US | claimed |
| CN-118961932-A | Method and system for detecting ritonavir intermediate | 武汉海特生物创新医药研究有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-112592324-A | Method for purifying ritonavir intermediate raw material | 盐城迪赛诺制药有限公司 | 2021-04-02 | — | — | CN | disclosed |
| CN-112500367-A | Refining method of ritonavir intermediate | 盐城迪赛诺制药有限公司 | 2021-03-16 | — | — | CN | disclosed |
| US-5354866-A | Treating HIV infections | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1994014436-A1 | RETROVIRAL PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1994-07-07 | — | — | WO | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |