Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961026 | 0.84 | GBA2 (0.41) | TSHRCYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL7596565 | 0.84 | TSHR (0.39) | TSHRCYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL505525 | 0.83 | TSHR (0.50) | TSHRMEN1KMT2ATHRBHTT | |
| SCHEMBL11026580 | 0.83 | CYP4F2 (0.41) | TSHRCYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL19426852 | 0.80 | MEN1 (0.41) | TSHRCYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL28256867 | 0.80 | TSHR (0.36) | TSHRCYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL16099119 | 0.80 | TSHR (0.36) | TSHRCYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL17932920 | 0.80 | TSHR (0.41) | TSHRCYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL18961748 | 0.80 | TSHR (0.41) | TSHRMEN1KMT2ATHRBHTT | |
| SCHEMBL14452967 | 0.80 | TSHR (0.55) | TSHRMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573848-B1 | Bile-acid derivatives, a process for their production and their use as medicines | HOECHST AG (DE) | 1997-12-03 | — | — | EP | disclosed |
| US-5428182-A | Hypolipidemic agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-06-27 | — | — | US | disclosed |
| EP-0573848-A2 | Bile-acid derivatives, a process for their production and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-12-15 | — | — | EP | disclosed |