Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | CDK7 | P50613 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | LTK | P29376 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.56 |
| ▸ | MST1R | Q04912 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635530 | 1.00 | NTRK1 (0.56) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8639103 | 0.89 | NTRK1 (0.65) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8584213 | 0.84 | NTRK1 (0.64) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8584217 | 0.84 | NTRK1 (0.64) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8585618 | 0.79 | NTRK1 (0.67) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8583222 | 0.79 | NTRK1 (0.77) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8583220 | 0.79 | NTRK1 (0.77) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8585615 | 0.79 | NTRK1 (0.67) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8586372 | 0.77 | NTRK1 (0.63) | NTRK1NTRK3NTRK2RETCDK7 | |
| SCHEMBL8586376 | 0.77 | NTRK1 (0.63) | NTRK1NTRK3NTRK2RETCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |