SCHEMBL8935258

SCHEMBL8935258

CNC(=O)C(N)(CO)Cc1ccc(OCc2cccc(F)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAOB P27338 10/20 0.54
PARP10 Q53GL7 1/20 0.54
MAOA P21397 1/20 0.53
SCN9A Q15858 1/20 0.53
NR4A2 P43354 1/20 0.52
GRM5 P41594 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8935383 0.87 MAOB (0.57) MAOBNR4A2
SCHEMBL8935303 0.87 MAOB (0.54) MAOBMAOA
SCHEMBL8935363 0.85 MAOB (0.54) MAOBPARP10MAOASCN9ANR4A2
SCHEMBL8935318 0.81 SCN3A (0.53) MAOBPARP10SCN9A
SCHEMBL8935253 0.80 MAOB (0.54) MAOBPARP10MAOASCN9ANR4A2
SCHEMBL8935242 0.80 MAOB (0.51) MAOBPARP10MAOANR4A2
SCHEMBL8935237 0.80 MAOB (0.51) MAOBPARP10MAOANR4A2
SCHEMBL8935241 0.78 MAOB (0.63) MAOBPARP10MAOASCN9ANR4A2
SCHEMBL4425163 0.78 MAOB (0.60) MAOBPARP10MAOASCN9ANR4A2
SCHEMBL3971368 0.78 MAOB (0.58) MAOBPARP10MAOASCN9ANR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5502079-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS FARMITALIA CARLO ERBA S.R.L. (IT) 1996-03-26 US disclosed