Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.63 |
| ▸ | TTPA | P49638 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935467 | 1.00 | NR1I2 (0.65) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL4271100 | 1.00 | NR1I2 (0.65) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL30859422 | 1.00 | NR1I2 (0.65) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL8603306 | 0.91 | NR1I2 (0.70) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL3524416 | 0.89 | NR1I2 (0.67) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL27200182 | 0.89 | NR1I2 (0.67) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL23867134 | 0.88 | MAPT (0.63) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL27295634 | 0.88 | MAPT (0.63) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL2176872 | 0.88 | NR1I2 (0.61) | NR1I2MAPTLMNAUSP2CYP2C9 | |
| SCHEMBL5672022 | 0.88 | NR1I2 (0.61) | NR1I2MAPTLMNAUSP2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122426-B1 | OPTICALLY ACTIVE CHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES | BASF Aktiengesellschaft (DE) | 1988-01-27 | — | — | EP | claimed |
| EP-0122426-A2 | Optically active chroman derivatives, process for their preparation and intermediates | BASF Aktiengesellschaft (DE) | 1984-10-24 | — | — | EP | claimed |
| JP-3215481-A | — | — | None | — | — | JP | disclosed |
| US-5504219-A | Optically active compounds and intermediates thereof, and process for manufacturing same | ASAHI DENKA KOGYO K.K. (JP) | 1996-04-02 | — | — | US | disclosed |
| EP-0441116-B1 | Process and intermediates for the manufacture of optically active chroman derivatives | ASAHI DENKA KOGYO KK (JP) | 1995-04-05 | — | — | EP | disclosed |
| US-5352845-A | Process for manufacture of optically active saturated compounds | ASAHI DENKA KOGYO K.K. (JP) | 1994-10-04 | — | — | US | disclosed |
| US-5262552-A | Optically active compounds and intermediates thereof, and process for manufacturing same | ASAHI DENKA KOGYO K.K. (JP) | 1993-11-16 | — | — | US | disclosed |
| US-5233056-A | Optically active chroman derivatives and intermediates thereof, and process for manufacturing same | ASAHI DENKA KOGYO K.K. (JP) | 1993-08-03 | — | — | US | disclosed |
| JP-H03215481-A | OPTICALLY ACTIVE CHROMAN-2-ETHANOL DERIVATIVE AND ITS INTERMEDIATE | ASAHI DENKA KOGYO KK | 1991-09-20 | — | — | JP | disclosed |
| EP-0441116-A2 | Process and intermediates for the manufacture of optically active chroman derivatives | ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) | 1991-08-14 | — | — | EP | disclosed |
| EP-0122426-B1 | OPTICALLY ACTIVE CHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES | BASF Aktiengesellschaft (DE) | 1988-01-27 | — | — | EP | disclosed |
| US-4645845-A | Novel optically active chroman derivatives, their preparation and novel intermediates | BASF AKTIENGESELLSCHAFT (DE) | 1987-02-24 | — | — | US | disclosed |
| EP-0122426-A2 | Optically active chroman derivatives, process for their preparation and intermediates | BASF Aktiengesellschaft (DE) | 1984-10-24 | — | — | EP | disclosed |