Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.52 |
| ▸ | JAK3 | P52333 | 7/20 | 0.52 |
| ▸ | BTK | Q06187 | 14/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893555 | 1.00 | LCK (0.52) | LCKJAK3BTKEGFR | |
| SCHEMBL894824 | 0.89 | LCK (0.58) | LCKJAK3BTKEGFR | |
| SCHEMBL894992 | 0.85 | LCK (0.55) | LCKJAK3BTKEGFR | |
| SCHEMBL894994 | 0.85 | LCK (0.55) | LCKJAK3BTKEGFR | |
| SCHEMBL894624 | 0.84 | BTK (0.67) | LCKJAK3BTKEGFR | |
| SCHEMBL894625 | 0.84 | BTK (0.67) | LCKJAK3BTKEGFR | |
| SCHEMBL1704987 | 0.84 | LCK (0.56) | LCKJAK3BTKEGFR | |
| SCHEMBL893937 | 0.83 | BTK (0.53) | LCKJAK3BTKEGFR | |
| SCHEMBL893939 | 0.83 | BTK (0.53) | LCKJAK3BTKEGFR | |
| SCHEMBL10169544 | 0.76 | LRRK2 (0.47) | LCKJAK3BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586751-B2 | Nicotinamide compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-19 | — | — | US | disclosed |
| EP-2440204-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | Bristol-Myers Squibb Company (US) | 2012-04-18 | — | — | EP | disclosed |
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
| WO-2010144647-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | NADK, BTK, NAMPT | LCK 31/4885JAK3 418/4885BTK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.