SCHEMBL8935802

SCHEMBL8935802

c1cncc(-c2ccc(-c3cccnc3)nc2)c1

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 8/20 0.69
CYP3A4 P08684 2/20 0.69
ALDH1A1 P00352 1/20 0.65
CYP1A2 P05177 1/20 0.65
MKNK1 Q9BUB5 3/20 0.53
MKNK2 Q9HBH9 3/20 0.53
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA9 Q16790 1/20 0.52
HSP90AA1 P07900 1/20 0.52
HSP90AB1 P08238 1/20 0.52
PTK2 Q05397 1/20 0.52
CYP11B2 P19099 4/20 0.51
CYP11B1 P15538 3/20 0.51
KIF11 P52732 1/20 0.50
METAP2 P50579 1/20 0.50
SIRT3 Q9NTG7 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6279050 0.94 CYP2A6 (0.63) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL15459109 0.89 CYP2A6 (0.58) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL9973776 0.89 CYP2A6 (0.57) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL17055547 0.89 CYP2A6 (0.67) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL12339163 0.89 CYP2A6 (0.77) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL24871232 0.89 CYP2A6 (0.57) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL15459068 0.89 CYP2A6 (0.58) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL18745763 0.89 CYP2A6 (0.57) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL15459160 0.89 CYP2A6 (0.58) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL3509967 0.88 CYP2A6 (0.85) CYP2A6CYP3A4ALDH1A1CYP1A2HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140066627-A1 ORGANIC LIGHT EMITTING HOST MATERIALS NITTO DENKO CORPORATION (JP) 2014-03-06 US claimed
US-9263681-B2 Organic light emitting host materials NITTO DENKO CORPORATION (JP) 2016-02-16 US disclosed
US-9172051-B2 Organic light emitting host materials NITTO DENKO CORPORATION (JP) 2015-10-27 US disclosed
WO-2014093353-A1 ORGANIC LIGHT EMITTING POLYAROMATIC AND POLYHETEROAROMATIC HOST MATERIALS NITTO DENKO CORPORATION (JP) 2014-06-19 WO disclosed
US-20140159015-A1 ORGANIC LIGHT EMITTING HOST MATERIALS NITTO DENKO CORPORATION (JP) 2014-06-12 US disclosed
US-20140066627-A1 ORGANIC LIGHT EMITTING HOST MATERIALS NITTO DENKO CORPORATION (JP) 2014-03-06 US disclosed
CN-101918362-B Pyridine derivatives NOVARTIS AG 2013-11-27 CN disclosed
CN-101918362-A Pyridine derivatives NOVARTIS AG 2010-12-15 CN disclosed
CN-101326181-A Imidazopyridine derivatives as a2b adenosine receptor antagonists ALMIRALL LAB (ES) 2008-12-17 CN disclosed
CN-1332727-A 3, 3-diarylpiperidine and 2, 2-diarylmorpholine derivatives PFIZER PROD INC (US) 2002-01-23 CN disclosed
US-5559214-A Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods STERLING WINTHROP INC. (US) 1996-09-24 US disclosed