Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2538783 | 0.84 | KDM4E (0.66) | POLBKDM4ECYP3A4CYP2C19HIF1A | |
| SCHEMBL6492060 | 0.84 | POLB (1.00) | POLBNR4A2KDM4EKMT2AMEN1 | |
| SCHEMBL3420261 | 0.84 | POLB (0.52) | POLBKDM4ECYP3A4CYP2C19HIF1A | |
| SCHEMBL7424524 | 0.81 | CYP2C19 (0.49) | POLBKDM4ECYP3A4CYP2C19HIF1A | |
| SCHEMBL5434270 | 0.81 | KDM4E (0.50) | POLBKDM4ECYP3A4CYP2C19HIF1A | |
| SCHEMBL1600117 | 0.81 | KDM4E (0.49) | POLBNR4A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL3060777 | 0.81 | KDM4E (0.49) | POLBNR4A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL5437258 | 0.81 | KDM4E (0.49) | POLBNR4A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL29893224 | 0.81 | KDM4E (0.49) | POLBNR4A2KDM4ECYP3A4CYP2C19 | |
| SCHEMBL5638415 | 0.79 | POLB (0.50) | POLBNR4A2KMT2AMPOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510338-A | ADMINISTERING TO A MAMMAL TO RELIEVE PAIN AND TO TREAT CONVULSIONS, CEREBRAL ISCHEMIC DAMAGE, AND EMESIS | GUILFORD PHARMACEUTICALS INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5342946-A | Phosphonoalkylquinolin-2-ones as novel antagonists of non-NMDA ionotropic excitatory amino acid receptors | GUILFORD PHARMACEUTICALS INC. (US) | 1994-08-30 | — | — | US | disclosed |