Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.46 |
| ▸ | SLCO2B1 | O94956 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | UGT1A1 | P22309 | 2/20 | 0.46 |
| ▸ | CCKAR | P32238 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | GHSR | Q92847 | 2/20 | 0.46 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 19/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL892885 | 0.95 | CYP3A4 (0.48) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL893751 | 0.93 | UGT1A1 (0.56) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL893666 | 0.91 | CYP3A4 (0.47) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL9943654 | 0.86 | CYP3A4 (0.52) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL4252192 | 0.86 | CYP3A4 (0.52) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL4960834 | 0.86 | CYP3A4 (0.49) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL892787 | 0.86 | CYP3A4 (0.49) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL892866 | 0.86 | CYP3A4 (0.53) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL893702 | 0.86 | CYP3A4 (0.53) | MLNRNR1I2SLCO2B1ABCB11ABCB1 | |
| SCHEMBL893090 | 0.86 | CYP3A4 (0.52) | MLNRNR1I2SLCO2B1ABCB11ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243340-A1 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | ABBVIE INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20120083490-A1 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083490-A1 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | CYP3A43, CYP3A5, POR | MLNR 1233/4885NR1I2 327/4885SLCO2B1 85/4885 |
| US-20140243340-A1 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | CYP3A43, CYP3A5, POR | MLNR 1233/4885NR1I2 327/4885SLCO2B1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.