Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.76 |
| ▸ | ACHE | P22303 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | FDPS | P14324 | 3/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937454 | 1.00 | KDM4E (0.76) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937290 | 1.00 | KDM4E (0.76) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937445 | 0.94 | KDM4E (0.67) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937352 | 0.94 | KDM4E (0.67) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937349 | 0.94 | KDM4E (0.67) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937412 | 0.94 | KDM4E (0.65) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937409 | 0.94 | KDM4E (0.65) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937414 | 0.94 | KDM4E (0.65) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937301 | 0.91 | KDM4E (0.60) | KDM4EACHEALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8937431 | 0.91 | KDM4E (0.60) | KDM4EACHEALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |