Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937473 | 1.00 | KMT2A (0.67) | KMT2ANR1H4KAT6ASMN1; SMN2LMNA | |
| SCHEMBL8937464 | 1.00 | KMT2A (0.67) | KMT2ANR1H4KAT6ASMN1; SMN2LMNA | |
| SCHEMBL13236855 | 0.92 | KMT2A (0.59) | KMT2ANR1H4KAT6APLA2G4BSMPD1 | |
| SCHEMBL8937303 | 0.90 | KMT2A (0.60) | KMT2ANR1H4KAT6ASMN1; SMN2LMNA | |
| SCHEMBL8937434 | 0.90 | KMT2A (0.60) | KMT2ANR1H4KAT6ASMN1; SMN2LMNA | |
| SCHEMBL8937306 | 0.90 | KMT2A (0.60) | KMT2ANR1H4KAT6ASMN1; SMN2LMNA | |
| SCHEMBL8937565 | 0.83 | MAPT (0.60) | KMT2ANR1H4SMN1; SMN2LMNANPC1 | |
| SCHEMBL8937571 | 0.83 | MAPT (0.60) | KMT2ANR1H4SMN1; SMN2LMNANPC1 | |
| SCHEMBL8937615 | 0.83 | MAPT (0.60) | KMT2ANR1H4SMN1; SMN2LMNANPC1 | |
| SCHEMBL11696519 | 0.81 | KMT2A (0.77) | KMT2ANR1H4KAT6ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |