Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937654 | 1.00 | MAPT (0.53) | MAPTALDH1A1TTRDPP4CA12 | |
| Ethyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL1895653 | 0.88 | MAPT (0.58) | MAPTALDH1A1TTRDPP4CA12 | |
| SCHEMBL31462827 | 0.88 | MAPT (0.50) | MAPTALDH1A1TTRDPP4CA12 | |
| Ethyl 3-(2,4-Dichlorophenyl)Acrylate SCHEMBL1895655 | 0.88 | MAPT (0.58) | MAPTALDH1A1TTRDPP4CA12 | |
| SCHEMBL30087204 | 0.87 | MAPT (0.47) | MAPTALDH1A1TTRDPP4CA12 | |
| SCHEMBL29170149 | 0.87 | MAPT (0.47) | MAPTALDH1A1TTRDPP4CA12 | |
| SCHEMBL28283048 | 0.87 | TTR (0.58) | MAPTALDH1A1TTRDPP4CA12 | |
| SCHEMBL31462784 | 0.87 | MAPT (0.49) | MAPTALDH1A1TTRDPP4CA12 | |
| SCHEMBL28283049 | 0.87 | TTR (0.58) | MAPTALDH1A1TTRDPP4CA12 | |
| SCHEMBL7922171 | 0.86 | MAPT (0.46) | MAPTALDH1A1TTRDPP4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |