Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937339 | 1.00 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL8937344 | 1.00 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL1160850 | 0.90 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL1160848 | 0.90 | KDM4E (0.72) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL8999226 | 0.86 | ABCG2 (0.60) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL8937409 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL8937414 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL8937412 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL28397201 | 0.85 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL28397202 | 0.85 | KDM4E (0.78) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |