Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9491238 | 0.87 | TDP1 (0.54) | TDP1DPP4GAAALDH1A1MAPT | |
| SCHEMBL13495393 | 0.81 | DPP4 (0.47) | DPP4ALDH1A1TYMS | |
| SCHEMBL2081294 | 0.80 | GAA (0.62) | TDP1GAAALDH1A1MAPTHTT | |
| Water SCHEMBL8678452 | 0.78 | GAA (0.60) | TDP1GAAALDH1A1MAPTHTT | |
| Water SCHEMBL8678453 | 0.78 | GAA (0.60) | TDP1GAAALDH1A1MAPTHTT | |
| SCHEMBL28334287 | 0.78 | POLB (0.48) | TDP1DPP4TYMS | |
| SCHEMBL13700531 | 0.77 | TYMS (0.47) | DPP4TYMS | |
| SCHEMBL13707191 | 0.76 | TDP1 (0.73) | TDP1GAAALDH1A1MAPTHTT | |
| SCHEMBL27614683 | 0.75 | TYMS (0.46) | DPP4TYMS | |
| SCHEMBL13700529 | 0.74 | TYMS (0.45) | DPP4TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635023-A4 | COVALENTLY CROSS-LINKED OLIGONUCLEOTIDES. | ISIS PHARMACEUTICALS INC (US) | 1996-03-20 | — | — | EP | disclosed |
| EP-0635023-A1 | COVALENTLY CROSS-LINKED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1995-01-25 | — | — | EP | disclosed |
| WO-1993018052-A1 | COVALENTLY CROSS-LINKED OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 1993-09-16 | — | — | WO | disclosed |