Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.42 |
| ▸ | SCN1A | P35498 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 4/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.39 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.39 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8934996 | 0.93 | MAP2K1 (0.58) | MAP2K1ROCK1SCN8ASCN1AMAOA | |
| SCHEMBL8939144 | 0.93 | ROCK1 (0.52) | MAP2K1ROCK1SCN8ASCN1AMEN1 | |
| SCHEMBL8935003 | 0.91 | MAP2K1 (0.57) | MAP2K1ROCK1SCN8ASCN1AMAOA | |
| SCHEMBL8938144 | 0.89 | MAP2K1 (0.53) | MAP2K1ROCK1SCN8ASCN1AMAOA | |
| SCHEMBL8938278 | 0.88 | MAP2K1 (0.59) | MAP2K1ROCK1SCN8ASCN1AMAOA | |
| SCHEMBL8937925 | 0.88 | ROCK1 (0.54) | MAP2K1ROCK1MAOAMAOBROCK2 | |
| SCHEMBL8938119 | 0.87 | MAP2K1 (0.55) | MAP2K1SCN8ASCN1AMAOAMAOB | |
| SCHEMBL8938641 | 0.87 | ROCK1 (0.54) | ROCK1MEN1KMT2AMAOAMAOB | |
| SCHEMBL8938150 | 0.87 | MAP2K1 (0.57) | MAP2K1ROCK1MEN1KMT2AMAOA | |
| SCHEMBL8934981 | 0.86 | MAP2K1 (0.59) | MAP2K1ROCK1SCN8ASCN1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |