Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 7/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.38 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.38 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR5A | P47898 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938108 | 0.91 | ROCK1 (0.58) | ROCK1MAP2K1ROCK2HTR7PRKACA | |
| SCHEMBL8938003 | 0.90 | ROCK1 (0.59) | ROCK1MAP2K1ROCK2PRKACAPRKCD | |
| SCHEMBL8939126 | 0.89 | ROCK1 (0.60) | ROCK1MAP2K1ROCK2PRKACAPRKCD | |
| SCHEMBL8938071 | 0.87 | ROCK1 (0.59) | ROCK1MAP2K1ROCK2PRKACAPRKCD | |
| SCHEMBL8938025 | 0.85 | ROCK1 (0.58) | ROCK1MAP2K1ROCK2PRKACAPRKCD | |
| SCHEMBL8938067 | 0.85 | ROCK1 (0.57) | ROCK1MAP2K1ROCK2PRKACAPRKCD | |
| SCHEMBL8938029 | 0.85 | ROCK1 (0.59) | ROCK1MAP2K1ROCK2PRKACAPRKCD | |
| SCHEMBL8938080 | 0.84 | ROCK1 (0.61) | ROCK1MAP2K1ROCK2PRKACAPRKCD | |
| SCHEMBL8939164 | 0.84 | ROCK1 (0.57) | ROCK1MAP2K1ROCK2PRKACAPRKCD | |
| SCHEMBL8938640 | 0.84 | ROCK1 (0.76) | ROCK1MAP2K1ROCK2PRKACAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |