Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.42 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.42 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.42 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2574135 | 0.87 | ROCK1 (0.56) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL2338800 | 0.86 | ROCK1 (0.49) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL2338803 | 0.86 | ROCK1 (0.49) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL12211464 | 0.82 | ROCK1 (0.50) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL12211483 | 0.82 | MAP2K1 (0.38) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL12211508 | 0.81 | ROCK1 (0.39) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL12211470 | 0.81 | ROCK1 (0.41) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL12211492 | 0.81 | ROCK1 (0.39) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL12211520 | 0.80 | MAP2K1 (0.38) | JAK2JAK1ROCK1MAP2K1ROCK2 | |
| SCHEMBL12211536 | 0.79 | ROCK1 (0.39) | JAK2JAK1ROCK1MAP2K1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |