Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8830322 | 0.89 | PNP (0.46) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL23352546 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL29502677 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL17521211 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL657819 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL9141685 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL21162582 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL8826276 | 0.87 | PNP (0.46) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL9360335 | 0.87 | PNP (0.46) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL9150000 | 0.86 | PDE4D (0.61) | PNPLMNATP53HTTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670328-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-09-06 | — | — | EP | claimed |
| EP-0317128-A2 | Anti-HIV Pyrimidine Nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-05-24 | — | — | EP | claimed |
| US-5574149-A | Method of treating HIV infections with 2',3'-dideoxy-3'-fluoro-5-chlorouridine | GLAXO WELLCOME INC. (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0670328-A1 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-09-06 | — | — | EP | disclosed |
| EP-0317128-A2 | Anti-HIV Pyrimidine Nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-05-24 | — | — | EP | disclosed |