Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.48 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.48 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872217 | 0.89 | SMN1; SMN2 (0.60) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2855664 | 0.88 | SMN1; SMN2 (0.58) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6969799 | 0.86 | SMN1; SMN2 (0.61) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18032527 | 0.83 | SMN1; SMN2 (0.54) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31435518 | 0.82 | SMN1; SMN2 (0.58) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4869972 | 0.78 | SMN1; SMN2 (0.60) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12815027 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL5866432 | 0.76 | CA1 (0.51) | HDAC1HDAC6F2PRSS1SMN1; SMN2 | |
| SCHEMBL23187621 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19L3MBTL1 | |
| SCHEMBL17825392 | 0.75 | SMN1; SMN2 (0.58) | HDAC1HDAC6SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726893-A1 | NOVEL 4-PIPERIDINYL SUBSTITUTED LACTAMES AS NEUROKININ 2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ASTHMA | ZENECA LIMITED (GB) | 1996-08-21 | — | — | EP | disclosed |
| US-5534525-A | Lactam derivatives | ZENECA LIMITED (GB) | 1996-07-09 | — | — | US | disclosed |