Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.57 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 4/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1607395 | 0.87 | CNR2 (0.57) | KDM4EEPHX2CA12CA1CA2 | |
| SCHEMBL1606703 | 0.86 | CA12 (0.67) | KDM4EEPHX2CA12CA1CA2 | |
| SCHEMBL20916882 | 0.85 | NPC1 (0.51) | VEGFAEGLN1KDM4EEPHX2CCR2 | |
| SCHEMBL31590800 | 0.85 | VEGFA (0.55) | VEGFAEGLN1KDM4ECA12CA1 | |
| SCHEMBL9022567 | 0.85 | CNR2 (0.57) | KDM4EEPHX2CA12CA1CA2 | |
| SCHEMBL24434754 | 0.85 | EPHX2 (0.51) | KDM4EEPHX2CA12CA1CA2 | |
| SCHEMBL12951306 | 0.84 | KDM4E (0.78) | EGLN1KDM4EEPHX2CNR2CCR2 | |
| SCHEMBL7186933 | 0.82 | FEN1 (0.51) | VEGFAEGLN1KDM4ECA12CA1 | |
| SCHEMBL24434943 | 0.81 | KDM4E (0.49) | KDM4EEPHX2CA12CA1CA2 | |
| SCHEMBL12803579 | 0.81 | VEGFA (0.51) | VEGFAEGLN1KDM4EEPHX2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846684-B2 | Arbovirus inhibitors and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846684-B2 | Arbovirus inhibitors and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846684-B2 | Arbovirus inhibitors and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-09-30 | — | — | US | disclosed |
| WO-2012170098-A2 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012170098-A2 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-12-13 | — | — | WO | disclosed |
| US-20120252807-A1 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-04 | — | — | US | disclosed |
| US-20120252807-A1 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-04 | — | — | US | disclosed |
| US-20120252807-A1 | ARBOVIRUS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-04 | — | — | US | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |
| US-5214204-A | Inhibitors of biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252807-A1 | ARBOVIRUS INHIBITORS AND USES THEREOF | ACE, ACE2, MME | VEGFA 3010/4885EGLN1 2578/4885KDM4E 1572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.