Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942461 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL8942071 | 0.89 | KDM4E (0.33) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8942070 | 0.89 | KDM4E (0.33) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8889403 | 0.82 | GAA (0.60) | KDM4EALDH1A1HPGDGAAPOLB | |
| SCHEMBL8889397 | 0.82 | GAA (0.60) | KDM4EALDH1A1HPGDGAAPOLB | |
| SCHEMBL8942235 | 0.79 | KDM4E (0.51) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL8350776 | 0.78 | KDM4E (0.48) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL8942506 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL8351962 | 0.74 | KDM4E (0.46) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL8942533 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | claimed |
| US-5482933-A | ANOXIA, ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-09 | — | — | US | disclosed |
| US-5480876-A | FROM ANOXIA OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1996-01-02 | — | — | US | disclosed |
| US-5302586-A | Antiischemic and -hypoxia agents, particularly after a stroke, cardiac arrest, hypoglycemia or perinatal asphxia | G. D. SEARLE & CO. (US) | 1994-04-12 | — | — | US | disclosed |